Les options thérapeutiques pour la rhinite allergique

Résumé du document

Le poids épidémiologique :
- Une fréquence croissante pour l'ensemble des régions du globe;
- 16 à 25% de fréquence brute dans la population générale.

Plusieurs théories tentent d'expliquer cette élévation de fréquence:
- Génétique;
- le mode de vie (alimentation, habitation,…);
- les changements climatiques;
- la pollution atmosphérique, etc…

Extraits

[...] Therefore, it is important to have attributes that minimise the systemic availability. Key points of information: A Phase I pharmacokinetic study (FFR10008) using an oral solution of radiolabelled drug demonstrated that at least 30% of FF is absorbed and the oral bioavailability is, on average This is indicative of extensive first-pass metabolism of FF. Although the contribution of direct nasal absorption to the overall bioavailability has not been determined, it is expected to be negligible. Clearance of FF is primarily by metabolism; FF is rapidly cleared (average total plasma clearance of 57.5 from the systemic circulation principally by hydrolysis in the liver by the cytochrome P450 enzyme CYP3A4 to a pharmacologically inactive 17 -carboxylic metabolite.2 References: GSK, data on file. [...]

[...] dans le monde Strachan D et al. Pediatr Allergy Immunol 1997;8:161 –76. Enfants entre 13 et 14 ans Australia Brazil China France Germany Greece India Indonesia Singapore South Africa Spain Sweden UK USA – to 14-year-olds (n=463, 801) Untitled-2.gif < number > Key message: The prevalence of AR is very high in school children, with rates ranging from 5–20%. Key points of information: The presented data is a subset analysis of the International Study of Asthma and Allergies in Childhood (ISAAC) conducted to investigate the prevalence of non-infective rhinitis, rhinoconjunctivitis (AR with itchy, watery eyes) and diagnosed hayfever. [...]

[...] Settipane RA. Allergy Asthma Proc 1999;20:209–13. Crystal-Peters J et al. J Allergy Clin Immunol 2002;109:57–62. Dykewicz MS et al. Ann Allergy Asthma Immunol 1998;81:478–518. International Rhinitis Management Working Group. Allergy 1994;49:1–34. [...]

[...] In the subset analysis presented in this slide, data were collected by means of participant-completed written questionnaires about their symptoms. Reference: Strachan D et al. Pediatr Allergy Immunol 1997;8:161–76. Base : AR sufferers (n=600) Nasal symptoms Ocular symptoms Other symptoms Sneezing Runny nose Blocked nose Itchy nose Itchy/red eyes Watery eyes Post-nasal drip Itchy palate Cough Percentage of PCPs Nasal symptoms only Ocular symptoms only Nasal and ocular symptoms Importance des symptômes oculaires dans la rhinite allergique Les symptômes courants avant le traitement Symptômes oculaires et nasaux en méd. [...]

[...] générale Van Cauwenberge P et al. Prim Care Respir J 2008; DOI: 10.3132 /pcrj Untitled-2.gif < number > < number > Key message: Over 50% of PCPs with AR have both nasal and ocular symptoms.1 Key points of information: Symptoms commonly reported by PCPs with AR included nasal symptoms, such as sneezing runny nose blocked nose and itchy nose and ocular symptoms, such as itchy/red eyes or watery eyes (39%).1 Both nasal and ocular symptoms were reported by 55% (n=326) of PCPs with AR; 41% (n=248) had nasal symptoms only.1 Data presented are from the PCP survey and are for those physicians experiencing AR symptoms (n=600). [...]